Advanced Acne Biohacking Skincare Routine

Severe forms of acne always require medical attention and should be treated according to your dermatologist’s recommendations.

If you have been struggling with acne for longer than 4–6 months, see more than 25–30 active lesions on half of your face, or notice painful, highly inflamed, or oozing breakouts, professional help is essential.

Conventional, guideline-based acne treatment is effective, but it can be uncomfortable and sensitizing because it often disrupts the skin microbiome and aggressively suppresses sebum production while speeding up cell turnover.

The Meder Advanced Acne Routine is designed as a microbiome-friendly, biohacking skincare system that complements medical care. It helps you achieve clearer skin faster while preserving comfort, restoring a healthy microbiome balance, and supporting more normal sebum gland function with gentle, non-irritating actives.

The Science Behind Advanced Acne Routine

This routine uses a multi-step microbiome and biohacking approach to help rebalance acne-prone skin without retinol, benzoyl peroxide, or salicylic acid: only gentle, advanced ingredients focused on restoring skin health.

  • Diverse prebiotics and probiotics at every step help suppress overgrowth of acne-associated C. acnes while promoting beneficial bacteria that protect the skin barrier and reduce inflammation, supporting a healthier microbiome from the first days of use.
  • A high concentration of bioactive niacinamide (4%) is backed by clinical data for acne-prone skin, helping normalize sebum production, calm redness, and improve texture with a well-tolerated, non-peeling mechanism.
  • Noni plant stem cell extract targets acne biofilm formation, disrupting the protective matrix around acne-causing bacteria and helping prevent comedones, clogged pores, and inflammatory flare-ups, while allowing beneficial flora to thrive.
  • An oil-free anti-acne moisturizer completes the routine, protecting vulnerable, treated skin from dehydration and irritation while maintaining a breathable, non-comedogenic finish. Independent microbiological testing shows that this microbiome-focused approach can significantly reduce virulent C. acnes strains and rebalance other key species like S. epidermidis, helping restore a healthier skin ecosystem and better barrier function.

This is true biohacking skincare: instead of harshly stripping the skin, it works with skin biology, microbiome signaling, and sebum regulation pathways to create a clearer, calmer, more resilient complexion over time.

Why No Retinol, Benzoyl Peroxide or Salicylic Acid

Many traditional anti-acne routines rely on retinoids, benzoyl peroxide, and strong acids, which can cause dryness, peeling, burning, and long-term barrier disruption, especially in sensitive or reactive skin.

The Meder Advanced Acne Routine avoids these irritants, instead using microbiome-supporting prebiotics/probiotics, niacinamide, and biofilm-targeting Noni stem cells to deliver effective, science-backed results with far less discomfort.

This makes it suitable as a long-term, biohacking-inspired solution for acne-prone skin, including those who cannot tolerate aggressive actives or who want to support skin health during prescription treatment.

Who This Routine Is For

  • People diagnosed with acne who want a comforting, microbiome-supportive companion to prescribed treatment.
  • Those suffering from chronic acne seeking a natural, retinol-free, benzoyl peroxide-free, and salicylic acid-free solution.
  • City dwellers and outdoor lovers with acne-prone skin exposed to sun, wind, and pollution, looking for barrier- and microbiome-friendly care.
  • People disappointed by traditional acne skincare that over-dries or irritates the skin.
  • Pregnant women and women in menopause experiencing acne breakouts who need a gentle, non-aggressive, biohacking skincare option.

Your 4-Step Daily Moment of Calm

Daily cost only $11.20

20% off when you get the whole routine.

Use the Meder Advanced Acne Skincare Routine morning and evening as a simple, 4-step ritual that fits easily into your daily life. In just a few minutes, you support your skin microbiome, optimize sebum regulation, calm inflammation, and strengthen the barrier, helping reduce the risk of future sensitivity and breakouts.


Turn your anti-acne care into a small act of self-care and skin biohacking: a quiet moment to breathe, reset, and give your skin the comfort, support, and intelligent science it deserves.

Key Benefits

Microbiome-friendly acne control

Helps rebalance acne-prone skin with prebiotics and probiotics, supporting a healthy skin microbiome while targeting acne-causing bacteria more gently than traditional harsh treatments.

Biohacking clear, calm skin

Uses advanced, non-aggressive biohacking actives (like niacinamide, Noni stem cells, and targeted complexes) to improve clarity, reduce breakouts, and support long-term skin resilience.

Supports skin barrier and comfort

Oil-free, non-stripping formulas protect and hydrate vulnerable, treated skin, helping reduce irritation, peeling, and sensitivity often seen with conventional acne therapies.

Optimizes sebum and reduces congestion

4% niacinamide helps normalize sebum production, refine texture, and minimize the look of clogged pores and comedones without over-drying the skin.

Free from retinol, benzoyl peroxide and salicylic acid

Delivers science-backed anti-acne results with a kinder approach, ideal for sensitive, reactive, pregnant, or retinol-intolerant skin types seeking a safer long-term solution.

Key ingredients

Wild Silver Mallow Extract
Centella Asiatica Extract
Alpine Water
Prebiotic Bioecolia
Probiotic Kimchi Extract
Noni stem cell extract
Maclura stem cell extract
Niacinamide (vit B3) 4%

Panthenol (vit B5)

Your 4-Step Routine to Calm, Clean and Healthy Skin

Step 1: Net-Apax prebiotic cleansing mask – a gentle, refreshing cleanse that removes impurities without stripping or burning, leaving sensitive skin soft and comfortable.
Step 2: Soin-Apax serum with Centella Asiatica – calms and comforts the skin, helping to reduce all types of inflammation and daily irritation.
Step 3: Eu-Seb Active Serum with Noni and Maclura stem cells, prebiotics and probiotic reduces inflammation while restoring skin comfort, freshness, and balance.
Step 4: Oil-free Eu-Skin moisturizer—Noni stem cells, Kimchi, and 4% niacinamide to soothe, hydrate, and brighten, no greasy residue or blocked pores.

How to Use

Start with Net-Apax Cleansing Mask. Apply evenly over the face, massage gently, and leave it on for a couple of minutes while you brush your teeth. Rinse off with lukewarm water.

Pat your skin dry with a paper towel, then apply one pump of Soin-Apax Sensitive Skin Serum to your face. Massage lightly until fully absorbed.

Follow by applying one pump of Eu-Seb Active Serum to your face. Massage lightly until fully absorbed.

Finish your routine with half a pump of Eu-Skin Moisturiser.Before going outdoors, always apply an oil-free sunscreen if your skin will be exposed to sunlight. For best results we recommend using this routine twice a day.

Adopt Anti-acne Lifestyle

Nourish skin with an anti-inflammatory diet. Prioritize fresh vegetables, fruits, and lean proteins with a focus on fish rich in omega‑3 fatty acids, and cut back on junk food, sugar, dairy, and red meat to help reduce inflammation and support clearer skin.

Hydrate with skin-friendly drinks. Drink plenty of water throughout the day and include green tea for its antioxidant and anti-inflammatory properties, helping your body and skin flush out toxins more efficiently.

Choose non-comedogenic sun and makeup products. Protect your skin daily with an oil-free, high-quality sunscreen and avoid sunscreens or makeup containing mineral oil or known irritants that can clog pores, trigger comedones, and worsen inflammation.

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